Systematic Review and Meta-Analysis: Predictors of Relapsing, Recurrent, and Chronic Depression in Young People

SD Tagliaferri; LKM Han; M Khetan; J Nguyen; C Markulev; S Rice; SM Cotton; M Berk; EM Byrne; D Rickwood; CG Davey; P Koval; A Ratheesh; PD McGorry; M Alvarez-Jimenez; L Schmaal

Journal article

Systematic Review and Meta-Analysis: Predictors of Relapsing, Recurrent, and Chronic Depression in Young People

SD Tagliaferri, LKM Han, M Khetan, J Nguyen, C Markulev, S Rice, SM Cotton, M Berk, EM Byrne, D Rickwood, CG Davey, P Koval, A Ratheesh, PD McGorry, M Alvarez-Jimenez, L Schmaal

Journal of the American Academy of Child and Adolescent Psychiatry | Elsevier BV | Published : 2026

DOI: 10.1016/j.jaac.2025.03.019

Abstract

Objective: Youth depression disrupts the social and vocational transition into adulthood. Most depression burden is caused by recurring or chronic episodes. Identifying young people at risk for relapsing, recurring, or chronic depression is critical. We systematically reviewed and meta-analyzed the literature on prognostic factors for relapsing, recurrent, and chronic depression in young people. Method: We searched the literature up (MEDLINE, PsycINFO, CINAHL, Embase, CENTRAL, WHO ICTRP, ClinicalTrials.gov, bioRxiv, MedRxiv) to March 6, 2024, and included cohort studies and randomized trials that assessed any prognostic factor for relapse, recurrence, or chronicity of depression in young peo..

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